Endocrine Abstracts

Background and Aim: We previously demonstrated that low-dose estradiol (E2) administered sublingually alone for 6 months in treatment-naïve trans women (TW), suppressed testosterone to the same degree, but generated higher serum E2 levels as the same oral dose combined with cyproterone acetate. We now sought to assess the possible differential impact of these approaches on anthropometric and body composition measurements, sex-dependent indicators with proven metabolic pro...

Background: The standard approach for Gender-Affirming Hormone Therapy (GAHT) of transgender women (TW) in Israel is oral estradiol (OE) combined with the potent anti-androgen cyproterone acetate (CA). Recently, many of our non-binary patients have requested sublingual estradiol (SLE) without CA, under the unproven belief it preserves erectile function, and does not induce depression. Preliminary data in a few subjects, who self-practiced this approach, suggested it also maint...